Effect of solvents on stabilization of micro drug particles

Document Type

Article

Publication Date

1-1-2011

Abstract

Antisolvent synthesis of micron scale Griseofulvin was carried out with simultaneous suspension stabilization under low power ultrasonic agitation. The organic solvent plays an important role because the supersaturation could be varied by using different solvents and the physicochemical characteristics of the suspension are also altered, which affects stability. In this study we present the effect of solvents on particle formation, polymorphism and stability of micron scale Griseofulvin formation in aqueous media. © 2010 Elsevier B.V. All rights reserved.

Identifier

78651060296 (Scopus)

Publication Title

Journal of Crystal Growth

External Full Text Location

https://doi.org/10.1016/j.jcrysgro.2010.11.153

ISSN

00220248

First Page

353

Last Page

358

Issue

1

Volume

314

Grant

0540855

Fund Ref

National Science Foundation

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