Document Type

Thesis

Date of Award

9-30-1988

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering Committee

First Advisor

David S. Kristol

Second Advisor

James A. Stackhouse

Third Advisor

Denis L. Blackmore

Abstract

In this study a dentin bonding agent based on Tolylene diisocyanatc with o chlorophenol as a blocking agent was tested. Bond strength with dentin was determined using a clinically relevant test method. A comparison was made using commercially available bonding agents and restorative resins. A simulation of microleakage around restorations was performed using a "Silver staining technique". Microleakage was quantified using digital image analysis, and a method was proposed to compensate for the loss of the third dimension during image analysis. Layer-by-layer curing of restorative, and an acid etching technique was used to improve bonding to dentin. The oral LD50 test was performed on 15 male rats as an initial screening test for toxicity.

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