"Computerized analysis of gastrointestinal spike burst activity" by Karthik Krishnan

Document Type

Thesis

Date of Award

9-30-1988

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering Committee

First Advisor

Stanley S. Reisman

Second Advisor

David S. Kristol

Abstract

This thesis describes a computer algorithm for locating gastrointestinal spike bursts. The algorithm also finds the the number of spikes within each spike burst, the average duration, and average amplitude of each spike burst. The algorithm was applied to the automation of the analysis of the Migrating Colonic Complex.

The algorithm detects the spike burst using threshold, time interval and frequency criteria. The computer program is implemented on a PDP 11/73 digital computer. The operation of the algorithm was tested on animal models to detect the spike bursts, before and after the inducement of certain drugs to alter the colonic motility. Tested against visual recognition, the reliability rate was above 90% and the misrecognition rate was less than 10%.

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