Document Type
Thesis
Date of Award
8-31-1991
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
Shlomo Gabbay
Second Advisor
David S. Kristol
Third Advisor
Clarence W. Mayott
Abstract
Thrombus formation is one of the major problems in artificial heart development and its clinical applications. In order to improve the antithrombogenesis in the artificial ventricles, three aspects of investigation have been done in the laboratory.
1] the surface features and the surface defects on specially prepared samples made of polyurethane and silicon rubber were studied and analyzed by scanning electron microscopy ( SEM ), light microscopy and KEVEX Feature Analysis for understanding and controlling the blood contacting surface.
2] the polyurethane blood contacting surface with smooth surface fabricated by solution cast process, the material treatment, and the fabrication procedure are developed and evaluated by in vitro blood test.
3] the diaphragm housing junction ( DHJ ), the connector system and the sealing method are studied and redesigned.
The results indicated that the surface morphology could be controlled by varying fabrication conditions. Air bubbles, open craters, dust and gel particles were four important surface defects which could be reduced by material filtration and quality control in the cast process. The newly developed polyurethane surface was smooth and free of surface defects. The in vitro blood test indicated the improved surface was less thrombogenic than before the new techniques were applied, and the surfaces with the surface defects would induce thrombus formation earlier than the smooth surface. The new designs of DHJ, connector system and sealing structure were recommended and discussed.
Recommended Citation
Wang, Hui-sun, "An approach to improving the antithrombogenesis of pneumatic diaphragm artificial ventricle : fabrication and design considerations" (1991). Theses. 2652.
https://digitalcommons.njit.edu/theses/2652
