Document Type
Thesis
Date of Award
12-31-1991
Degree Name
Master of Science in Electrical Engineering - (M.S.)
Department
Electrical Engineering
First Advisor
Peter Engler
Second Advisor
Stanley S. Reisman
Third Advisor
David S. Kristol
Abstract
The adequacy of a mathematical model in simulating temperature regulation in rats after resuscitation from hemorrhagic shock is investigated. This model, proposed elsewhere, was devised to study temperature profiles during hyperthermia in humans.
Hemorrhagic shock was achieved by bleeding rats to an average mean arterial pressure (MAP) of 30mmHg. The rats were then maintained at this MAP for up to four hours by withdrawing or reinfusing the shed blood. One group (the control group), was allowed to return to normal body temperature after the shock episode without external intervention. A second group (microwave group) was irradiated, for an average of 60 minutes after resuscitation from shock, with 8.5mW/cm2 of microwave power supplied by a 915 MHZ microwave generator. The specific absorption rate (SAR) resulting from this power level was calculated to be 1.4W/Kg.
The animals that were rewarmed after resuscitation showed a significantly higher long term survival (100%) than non-heated animals (62.5%). These high survival rates suggested that the shock state reached through this procedure not was sufficiently severe. Further research will be needed in which the animals will be subjected to more severe degrees of shock.
The temperature readings obtained from these experiments were compared to those obtained from a computer simulation of the mathematical model. The agreement between the two set of curves was adequate to suggest that this is indeed a model that should be further studied and refined.
Recommended Citation
Shungu, Kahambwe, "Temperature regulation post hemorrhagic shock in rats : atheoretical analysis" (1991). Theses. 2626.
https://digitalcommons.njit.edu/theses/2626
