Date of Award

Fall 1994

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering Committee

First Advisor

Andrew Ulrich Meyer

Second Advisor

Edward Joseph Haupt

Third Advisor

David S. Kristol

Abstract

The use of signal modeling of the oscillatory potential (OP) of the electroretinogram (ERG), in the study of cone-rod interaction is investigated. ERG response data were analyzed for red, orange, blue and white flashes on no background and with red flashes on a blue background (to suppress rod responses). The OP signals were extracted from the ERG by digital bandpass filtering and a signal model was fitted through a simplex algorithm to produce the parameters including "OP envelope-amplitude", latency in terms of "center-time" of the OP-envelope and OP frequency. Amplitude for red flashes with or without a blue background showed similar increases at high stimulus intensities. White and orange flashes produced higher amplitudes at all stimulus intensities, thus demonstrating the presence of rod OP within the signal. Latencies changed relatively little for pure cone stimuli with increasing intensities, while latency sharply reduced for responses for blue stimuli. Use of signal modeling provides a simple procedure for summarizing the characteristics of the OP in rods and cones over a range of amplitudes.

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