Document Type
Thesis
Date of Award
Fall 10-31-1996
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
Arthur B. Ritter
Second Advisor
David S. Kristol
Third Advisor
Stanley S. Reisman
Abstract
The hemodynamics of the ventricular septa] defect is studied using a mathematical modeling technique. A twelve-compartment windkessel model of cardiovascular system is used to study the hemodynamics of the ventricular septal defect. The VSD is incorporated into the model via a parallel flow from the left to right ventricles (left-to-right shunt). The resistance to flow through the shunt is used to characterize the severity of the defect. Changes in the severity of the shunt flow produces changes in the ratio of pulmonary to systemic flow in the circulation. When the pulmonary to systemic flow ratio is more than 2:1, the defect is considered large based on current clinical guidelines. A safe-limit shunt hemodynamic resistance corresponding to a ratio of 2:1 was found to be 0.33 mmHg/ml/sec. This is high compared with the normal resistance of the pulmonary valve (0.0333 mmHg/ml/sec), mitral valve (0.0334 mmHg/ml/sec) and aortic valve (0.02 mmHg/ml/sec). The model also predicted that increasing pulmonary artery resistance reduces the work load on the heart.
Despite the simplicity of the model, the results showed good agreement with available clinical and experimental data. This model provides a useful basis for analyzing the hemodynamics of ventricular septal defects.
Recommended Citation
Gupta, Adarsh Kumar, "Modeling of cardiovascular system to simulate ventricular septal defect" (1996). Theses. 1093.
https://digitalcommons.njit.edu/theses/1093
