Date of Award
Master of Science in Biomedical Engineering - (M.S.)
Biomedical Engineering Committee
Arthur B. Ritter
H. Michael Lacker
David S. Kristol
The renal system is known to participate in the natural regulation of blood pressure. A renal system model that simulates interaction responses of renal output to arterial blood pressure was developed. The major components of this model are glomerular filtration rate, tubular sodium reabsorption, the renin-angiotensin system, Aldosterone secretion, and antidiuretic hormone secretion. The model's differential equations were coded using Vissim 1.2 student version. It was found that, the renal output increased as glomerular filtration rate, Aldosterone concentration, and blood pressure increased. Conversely, increasing antidiuretic hormone concentration lead to decreased renal output.
Additionally, Angiotensin II and Aldosterone concentrations increased as the arterial pressure decreased. The model suggests that increasing renal output leads to decreased blood volume, which aids in the long term regulation of blood pressure.
Saume, Sami D., "Renin-angiotensin system and its relationship to arterial pressure regulation" (1997). Theses. 1032.