Document Type
Thesis
Date of Award
Spring 5-31-1997
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
Arthur B. Ritter
Second Advisor
H. Michael Lacker
Third Advisor
David S. Kristol
Abstract
The renal system is known to participate in the natural regulation of blood pressure. A renal system model that simulates interaction responses of renal output to arterial blood pressure was developed. The major components of this model are glomerular filtration rate, tubular sodium reabsorption, the renin-angiotensin system, Aldosterone secretion, and antidiuretic hormone secretion. The model's differential equations were coded using Vissim 1.2 student version. It was found that, the renal output increased as glomerular filtration rate, Aldosterone concentration, and blood pressure increased. Conversely, increasing antidiuretic hormone concentration lead to decreased renal output.
Additionally, Angiotensin II and Aldosterone concentrations increased as the arterial pressure decreased. The model suggests that increasing renal output leads to decreased blood volume, which aids in the long term regulation of blood pressure.
Recommended Citation
Saume, Sami D., "Renin-angiotensin system and its relationship to arterial pressure regulation" (1997). Theses. 1032.
https://digitalcommons.njit.edu/theses/1032
