The Organization of the Human Corpus Callosum Estimated by Intrinsic Functional Connectivity with White-Matter Functional Networks

Authors

Pan Wang, University of Electronic Science and Technology of China
Chun Meng, University of Electronic Science and Technology of China
Rui Yuan, Stanford University
Jianlin Wang, University of Electronic Science and Technology of China
Hang Yang, University of Electronic Science and Technology of China
Tao Zhang, University of Electronic Science and Technology of China
Laszlo Zaborszky, Center for Molecular and Behavioral Neuroscience
Tara L. Alvarez, Newark College of Engineering
Wei Liao, University of Electronic Science and Technology of China
Cheng Luo, University of Electronic Science and Technology of China
Huafu Chen, University of Electronic Science and Technology of China
Bharat B. Biswal, University of Electronic Science and Technology of China

Document Type

Article

Publication Date

5-14-2020

Abstract

The corpus callosum is the commissural bridge of white-matter bundles important for the human brain functions. Previous studies have analyzed the structural links between cortical gray-matter networks and subregions of corpus callosum. While meaningful white-matter functional networks (WM-FNs) were recently reported, how these networks functionally link with distinct subregions of corpus callosum remained unknown. The current study used resting-state functional magnetic resonance imaging of the Human Connectome Project test-retest data to identify 10 cerebral WM-FNs in 119 healthy subjects and then parcellated the corpus callosum into distinct subregions based on the functional connectivity between each callosal voxel and above networks. Our results demonstrated the reproducible identification of WM-FNs and their links with known gray-matter functional networks across two runs. Furthermore, we identified reliably parcellated subregions of the corpus callosum, which might be involved in primary and higher order functional systems by functionally connecting with WM-FNs. The current study extended our knowledge about the white-matter functional signals to the intrinsic functional organization of human corpus callosum, which could help researchers understand the neural substrates underlying normal interhemispheric functional connectivity as well as dysfunctions in various mental disorders.

Identifier

85084224218 (Scopus)

Publication Title

Cerebral Cortex

External Full Text Location

https://doi.org/10.1093/cercor/bhz311

e-ISSN

14602199

ISSN

10473211

PubMed ID

32080708

First Page

3313

Last Page

3324

Issue

5

Volume

30

Grant

61871420

Fund Ref

National Natural Science Foundation of China

Recommended Citation

Wang, Pan; Meng, Chun; Yuan, Rui; Wang, Jianlin; Yang, Hang; Zhang, Tao; Zaborszky, Laszlo; Alvarez, Tara L.; Liao, Wei; Luo, Cheng; Chen, Huafu; and Biswal, Bharat B., "The Organization of the Human Corpus Callosum Estimated by Intrinsic Functional Connectivity with White-Matter Functional Networks" (2020). Faculty Publications. 5303.
https://digitalcommons.njit.edu/fac_pubs/5303