Spontaneously formed unilamellar vesicles with path-dependent size distribution

Document Type

Article

Publication Date

7-19-2005

Abstract

We observe the spontaneous formation of path-dependent monodisperse and polydisperse phospholipid unilamellar vesicles (ULV) from two different equilibrium morphologies specifically, disklike micelles and extended lamellae, respectively. On heating beyond a temperature T c, low temperature disklike micelles, or so-called bicelles, transform into lamellae. Dilution of the lamellar phase, at a fixed temperature, results in a complete unbinding transition and the formation of polydisperse ULV, demonstrating the instability of the lamellar phase. On the other hand, heating of a dilute bicellar phase above T c results in monodisperse ULV, which on cooling revert back to bicelles for lipid concentrations φ ≥ 0.5 wt % and transform into oblate ellipsoids for φ = 0.1 wt %, a morphology not previously seen in "bicellar" lipid mixtures. Monodisperse ULV reform on heating of the oblate ellipsoids. © 2005 American Chemical Society.

Identifier

23144444013 (Scopus)

Publication Title

Langmuir

External Full Text Location

https://doi.org/10.1021/la0508994

ISSN

07437463

First Page

6656

Last Page

6661

Issue

15

Volume

21

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