Hypochlorite demonstrates anticoagulative properties

Document Type

Conference Proceeding

Publication Date

1-1-2002

Abstract

The hypochlorite ion (OCl) is a powerful oxidant that participates in the pathogenesis of ischemia/reperfusion injury, inflammation, and atherosclerosis. Whether hypochlorite has any anticoagulative properties in blood has previously not been investigated. We performed in vitro studies by spiking human citrated whole blood (CWB) with sodium hypochlorite (NaOCl) at final concentrations of 0 μg/mL (control), 9.5 μg/mL, and 95 μg/mL. The samples (n=12) were incubated at 37°C for 10 minutes and recalcified with 0.1 M CaCl2 to initiate clotting. The clotting or recalcification time (RT) was measured with a Sonoclot Coagulation Analyzer. The results indicate a significant prolongation (p<0.05) of clotting time with increasing concentrations of NaOCl. This data suggests that hypochlorite has anticoagulative properties.

Identifier

84948424228 (Scopus)

Publication Title

Proceedings of the IEEE Annual Northeast Bioengineering Conference Nebec

e-ISSN

21607001

ISSN

1071121X

First Page

43

Last Page

44

This document is currently not available here.

Share

COinS