Simultaneous synthesis, stabilization, and self-assembly of microscale drug particles in polymer films

Document Type

Article

Publication Date

5-15-2011

Abstract

The antisolvent synthesis of micrometer-scale particles, their stabilization in suspension, and their subsequent self-assembly as homogeneous polymer films suitable for drug delivery were studied. Ultrasonic agitation was used in the precipitation of the drug particulates, stabilization was carried out with hydroxypropyl methylcellulose (HPMC), and finally, drug-encapsulated films containing HPMC and polyvinylpyrrolidone were synthesized. These contained as much 28% of the drug Griseofulvin, and the particles were distributed uniformly throughout the films. Most importantly, the redispersion of the drug-loaded films in an aqueous matrix showed that the crystallinity remained unaltered, and there was no appreciable increase in the particle size distribution. © 2010 Wiley Periodicals, Inc.

Identifier

79951924825 (Scopus)

Publication Title

Journal of Applied Polymer Science

External Full Text Location

https://doi.org/10.1002/app.33342

e-ISSN

10974628

ISSN

00218995

First Page

2082

Last Page

2089

Issue

4

Volume

120

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