Date of Award

Spring 2010

Document Type

Thesis

Degree Name

Master of Science in Pharmaceutical Engineering - (M.S.)

Department

Chemical, Biological and Pharmaceutical Engineering

First Advisor

Piero M. Armenante

Second Advisor

Angelo J. Perna

Third Advisor

Laurent Simon

Abstract

The minimum agitation speed, NS, required to just suspend solid particles dispersed in water was experimentally determined in this work for a glass-lined type of mixing tank provided with a torispherical bottom and agitated with a retreat-blade impeller under different baffling configurations. Ns for the same tank but equipped with a different agitation system, namely an axial impeller, was also experimentally determined for the purpose of comparing of performances of the two systems. The effect of impeller off- bottom clearance and the vessel's liquid level on the minimum agitation speed were also experimentally studied. Njs, was experimentally determined using Zwietering's method, requiring that the solids do not rest on the tank bottom for more than 1-2 seconds. The value of Nis was found to depend strongly on the type of baffling, and was highest in the unbaffled tank and with solid particles 1501.1m in size and lowest in the partially baffled system.

The mixing time, θ95, required to disperse a tracer in the liquid to achieve a 95% homogeneity level was also experimentally determined in the same system for the partially baffled and fully baffled configurations. A colorimetric method coupled with image processing was used to determine the mixing time.

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