Document Type
Thesis
Date of Award
Spring 5-31-2004
Degree Name
Master of Science in Pharmaceutical Engineering - (M.S.)
Department
Chemical Engineering
First Advisor
Laurent Simon
Second Advisor
Piero M. Armenante
Third Advisor
Bozena B. Michniak
Abstract
In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.
Recommended Citation
Weltner, Alison Nickol, "Mathematical modeling of transient state transdermal drug delivery" (2004). Theses. 574.
https://digitalcommons.njit.edu/theses/574
