Date of Award

Spring 2004

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering

First Advisor

Michael Jaffe

Second Advisor

Roger Cubicciotti

Third Advisor

David S. Kristol

Fourth Advisor

Patricia Soteropoulos

Abstract

Nanotechnology is concerned with materials and systems whose structure and components exhibit novel and significantly improved physical, chemical and biological properties, phenomena and processes due to their nano scale size.

The transition from micro scale to nano scale leads to a number of changes in physical properties, possibly including new physical principles, some of which may be yet to be discovered. One of the major factors in this is the increase in ratio of surface area to volume.

This thesis research uses the increase in ratio of surface area to volume property of going from macro to micro to nano scale to pose the hypothesis that the increase in surface area to volume ratio as particle size gets smaller improves the functionality of immobilized molecular sensors.

In this thesis work we have successfully immobilized pseudo molecular beacons to paramagnetic particles of different sizes and shapes. The research has surprisingly concluded that the relationship between specific binding capacity and performance as measured by fluorescence binding capacity or performance labeling did not correlate inversely with particle sizes at fixed particle mass as originally postulated.

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