Date of Award
Master of Science in Bioinformatics - (M.S.)
Usman W. Roshan
Jason T. L. Wang
This thesis presents an analysis of multiple kernel learning (MKL) for type-1 diabetes risk prediction. MKL combines different models and representation of data to find a linear combination of these representations of the data. MKL has been successfully been implemented in image detection, splice site detection, ribosomal and membrane protein prediction, etc. In this thesis, this method was applied for Genome-wide association study (GWAS) for classifying cases and controls.
This thesis has shown that combined kernel does not perform better than the individual kernels and that MKL does not select the best model for this problem. Also, the effect of normalization on MKL as well as risk prediction has also been analyzed.
Garg, Paras, "Type-1 diabetes risk prediction using multiple kernel learning" (2010). Theses. 56.