Date of Award

Fall 2004

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering

First Advisor

Bharat Biswal

Second Advisor

Stanley S. Reisman

Third Advisor

Tara L. Alvarez

Abstract

Interest in brain hemodynamics has led to a substantial increase in state of the art research within the field of functional Magnetic Resonance Imaging (fMRI). FMRI enables research to be conducted on brain mapping in healthy individuals, as well as in patient populations. The need for accurate functional images is required. The primary objective was the development of a method to determine the optimal number of time points required to obtain reliable activation maps. The second phase involved the development of a program, which enabled the conversion of functional magnetic resonance images to a format that the neurosurgeon's scanner could read. Obtaining an accurate functional activation map by reducing the number of time points, in addition to converting it to a format which allows the surgeon to view the images in real-time on his scanner during stereo-tactic surgery will increase the success rate in brain surgery.

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