Document Type
Thesis
Date of Award
Summer 8-31-2006
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering
First Advisor
Treena Livingston Arinzeh
Second Advisor
Michael Jaffe
Third Advisor
George Collins
Abstract
The purpose of this study is to determine the potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) (PLLA), and poly(lactide-co-glycolide) (PLGA). Two types of HA-polymer solutions are first prepared to achieve HA weight percentage of 0, 10, and 25%of the total combined weight of HA and PLLA, and HA and PLGA. The solutions are electrospun to form nanofibrous mats incorporated with HA powder. A biomimetic process was also conducted as a secondary approach.
The nanofibrous mats obtained follow characterization using scanning electron microscope (SEM) - Energy Dispersive X-ray Analysis (EDXA), Thermogravimetric Analysis (TGA), and X-ray Diffraction (XRD). In this study, hydroxyapatite (HA) particles were successfully incorporated into the three dimensional porous biodegradable PLLA and PLGA polymer fiber mats by electrospinning.
Recommended Citation
Suzuki, Satomi, "Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application" (2006). Theses. 450.
https://digitalcommons.njit.edu/theses/450
