Date of Award
Master of Science in Biomedical Engineering - (M.S.)
Treena Livingston Arinzeh
The purpose of this study is to determine the potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) (PLLA), and poly(lactide-co-glycolide) (PLGA). Two types of HA-polymer solutions are first prepared to achieve HA weight percentage of 0, 10, and 25%of the total combined weight of HA and PLLA, and HA and PLGA. The solutions are electrospun to form nanofibrous mats incorporated with HA powder. A biomimetic process was also conducted as a secondary approach.
The nanofibrous mats obtained follow characterization using scanning electron microscope (SEM) - Energy Dispersive X-ray Analysis (EDXA), Thermogravimetric Analysis (TGA), and X-ray Diffraction (XRD). In this study, hydroxyapatite (HA) particles were successfully incorporated into the three dimensional porous biodegradable PLLA and PLGA polymer fiber mats by electrospinning.
Suzuki, Satomi, "Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application" (2006). Theses. 450.