Date of Award

Spring 2009

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering

First Advisor

Bryan J. Pfister

Second Advisor

Richard A. Foulds

Third Advisor

Max Roman

Abstract

Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies.

In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents.

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