Document Type


Date of Award


Degree Name

Master of Science in Chemical Engineering - (M.S.)


Chemical Engineering

First Advisor

C. L. Mantell

Second Advisor

James A. Bradley

Third Advisor

Saul I. Kreps


The mixed-acid nitration of 2-amino-5-chloropyridine has been studied and improvements in yield and quality made.

2-Nitramino-5-chloropyridine has been prepared in high purity with a yield of 87.5%, an improvement over the results of Stokes, who reported 80.0%, and Harris, who reported 63.0%, as their best yields. The quality of the product, as indicated by melting points, has been increased.

This improvement involves the addition of 2-amino-5-chloropyridine to a pre-mixed nitrating acid. This nitrating acid consists of sulfuric acid and nitric acid. The composition is based on an optimum nitric ratio of 1.04, and an optimum D.V.S. of 2.25.



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