Document Type


Date of Award


Degree Name

Master of Science in Biomedical Engineering - (M.S.)


Biomedical Engineering Committee

First Advisor

Peter Engler

Second Advisor

Swamy Laxminarayan

Third Advisor

Joseph J. McArdle

Fourth Advisor

David S. Kristol


Mathematical modelling and computer simulations of neurons was presented by various researchers in the past. Computer simulations provide a time efficient and cost effective method to obtain required information about the physiological system. The objective of this project is to study the kinetics of calcium channels in hippocampal neurons. In an attempt to study the calcium channel activity we have developed a mathematical model for the CA3 region of the hippocampus and have analysed the calcium current noise obtained from the physiological recordings. The Simulation results had reproduced the action potential and activities of sodium and potassium channels, but did not reproduce the calcium channel activity. The fluctuation analysis of calcium channels indicated there are two different processes associated with the calcium channels in hippocampal neurons.



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