Date of Award
Master of Science in Chemical Engineering - (M.S.)
Saul I. Kreps
Edward G. Scheibel
After a review of the various methods found in the literature, a series of reactions were selected which were reported to have good yields.
Using p-nitrotoluene as a starting material, a simultaneous oxidation and reduction with sodium polysulfide was investigated as a means of making p-aminobenzaldehyde. Experimental procedures and yields were reported, and improved methods of recovery were described.
Using p-aminobenzaldehyde from the first reaction, a condensation with malonic acid, in pyridine-piperidine medium, was investigated as a means of preparing p-aminocinnamic acid.
A recommended procedure was described, and some suggestions were made concerning the completion of the synthesis of p-acetamidocinnamic esters.
Fix, William Grayson, "Intermediates for p-acetamidocinnamic ester synthesis" (1955). Theses. 2290.