Date of Award
Master of Science in Applied Mathematics - (M.S.)
Amitabha Koshal Bose
Horacio G. Rotstein
Bright Light Therapy has been shown to be efficacious to mood disorders including Major Depression. Researchers use the Jewett-Forger-Kronauer model of the circadian rhythm with the Unified Model of melatonin including a mathematical term implementing feedback from the melatonin system into the circadian system to quantify the effects of bright light. Early investigations into intrinsic period, light sensitivity, and the circadian pacemaker's sensitivity to blood melatonin concentration may be indicators of subsets of patients with long intrinsic periods exhibiting symptoms of depression.
Mainwaring, Charles A., "Bright light therapy and depression: assessing suitability using entrainment maps" (2023). Theses. 2187.