Document Type


Date of Award


Degree Name

Master of Science in Chemical Engineering - (M.S.)


Chemical Engineering, Chemistry and Environmental Science

First Advisor

Gordon Lewandowski

Second Advisor

Basil Baltzis

Third Advisor

Piero M. Armenante


A dynamic model of a fill-and-draw reactor has been developed, which includes a number of operational parameters, the fraction of total cycle time devoted to fill, reaction and draw, and the concentration of the toxic substance in the feed to the reactor.

Operating diagrams have been generated, from which one can choose suitable operating parameters.

The model has been solved numerically for Andrews kinetics ( substrate inhibition ), and tested experimentally, using a 5-liter fill-and-draw reactor with phenol as sole carbon source and a pure culture of Pseudomonas putida. Results compared very well to the model predictions.