Document Type

Thesis

Date of Award

12-31-2021

Degree Name

Master of Science in Chemical Engineering - (M.S.)

Department

Chemical and Materials Engineering

First Advisor

Ecevit Atalay Bilgili

Second Advisor

Kathleen McEnnis

Third Advisor

Roman S. Voronov

Abstract

The aim of this study is to explore the feasibility of rotary evaporation for drying wetmilled drug suspensions as a novel approach to produce drug nanocomposites that exhibit fast redispersion and immediate drug release. To this end, the physical stability of the nanomilled itraconazole (drug) suspensions, a.k.a., nanosuspensions, during the milling and storage; the drying of the itraconazole nanosuspensions via the rotary evaporator; and the type/loading of various polymers/surfactants (dispersants) on aqueous redispersion and drug release from the nanocomposites were examined. Our results suggest that smaller drug particle size, owing to nanomilling, and smaller nanocomposite particle size, owing to optimized drying and subsequent mortar-pestle milling, as well as higher concentration of hydrophilic polymers/surfactants enhanced redispersion and drug release. Overall, rotary evaporation of drug nanosuspensions could achieve fast redispersion and immediate release of poorly soluble drugs from these nanocomposites, with less concern over potential flowability issues than spray-dried nanocomposites.

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