Date of Award

8-31-2020

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering

First Advisor

Bharat Biswal

Second Advisor

Sergei Adamovich

Third Advisor

Xiaobo Li

Fourth Advisor

Xin Di

Abstract

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related measures in a longitudinal analysis. The hypothesis is that with the age and group (AD or HC) of the subject, it is possible to separate AD and HC subjects from each other using 3 different ROIs (DMN – MT – MV), These regions are known to show abnormalities in AD patients but clinical wise never been identified as neuroimaging biomarkers. This study tries to check these ROIs to see if there are significant differences between the AD patients and HCs using 3 different features.

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