Document Type


Date of Award

Spring 5-31-1994

Degree Name

Master of Science in Applied Chemistry - (M.S.)


Chemical Engineering, Chemistry and Environmental Science

First Advisor

Carol A. Venanzi

Second Advisor

Tamara M. Gund

Third Advisor

James M. Grow


Stereolithography, a process by which a computer-guided Ultraviolet (UV) laser is applied onto a liquid monomer resin to form a solid polymer, was used to create solid models of amiloride and two of its analogues. The Cartesian coordinates used as input for the orientation of each atom in a molecule were calculated using ab initio molecular orbital theory. Since the structures of the molecules are calculated in this fashion, they represent a more accurate representation of the molecules than that provided by standard molecular modeling kits.

The original purpose of this work was to assist a blind chemist in appreciating the structure of amiloride and two of its analogues. The models not only serve blind individuals, but also serve as a communication link between blind and sighted individuals. The models also have the potential to be used as learning aides to blind and sighted students at the high school and college level.

Included in

Chemistry Commons



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