Date of Award

Spring 5-31-2017

Document Type

Thesis

Degree Name

Master of Science in Chemical Engineering - (M.S.)

Department

Chemical, Biological and Pharmaceutical Engineering

First Advisor

Roman S. Voronov

Second Advisor

S. Basuray

Third Advisor

Max Roman

Abstract

Thrombo-embolic infarction is the major cause of mortality and morbidity in the United States, causing over 1 million strokes, heart attacks and other life-threatening thrombotic events each year in the United States. Conversely, deficiencies in these processes result in severe bleeding risks. The ability to access hydrodynamics stresses at which thrombus structure is likely to embolize can provide insight into the thrombogenesis process. Interestingly, the viscoelastic behavior exhibited by the thrombus resembles that of a Bingham fluid - a material that behaves as a rigid body at low stresses but flows as a viscous fluid when the stress exceeds critical yield stress. Hence, we decided to measure the critical yield stress at which the thrombi yield (and possibly emboli). The fluid-induced stresses are calculated via Lattice-Boltzmann fluid dynamic simulation based on in vivo microscopic images of laser injury-induced thrombi and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks of occlusion and embolism in patients.

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