Document Type

Thesis

Date of Award

Fall 10-31-1992

Degree Name

Master of Science in Biomedical Engineering - (M.S.)

Department

Biomedical Engineering Committee

First Advisor

Samir S. Sofer

Second Advisor

David S. Kristol

Third Advisor

Arthur B. Ritter

Abstract

A simple mathematical model and simulation of the progression of cancer with particular emphasis on Cutaneous T Cell Lymphoma was investigated. The mathematical model consists of a set of differential equations that first satisfies the homeostasis levels of the different components present and second predicts the dynamics during a diseased or unhealthy condition. The simulation was done using a FORTRAN program for integrating the differential equations.

Simulation of the immune system is important in evaluating the usefulness of particular sorts of biologically targeted therapies and in selecting the most promising treatment strategies for clinical trials. In particular, the effects of leukapheresis and photopheresis in the treatment of CTCL was investigated using the model and available data. Simulation is also important for testing the effectiveness of new drugs on the system.

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.