Document Type

Thesis

Date of Award

Fall 1-31-2017

Degree Name

Master of Science in Chemical Engineering - (M.S.)

Department

Chemical, Biological and Pharmaceutical Engineering

First Advisor

S. Basuray

Second Advisor

Robert Benedict Barat

Third Advisor

Laurent Simon

Fourth Advisor

Dong Kyun Ko

Abstract

Temperature measurement and manipulation is a critical factor in a wide range of applications like Point Of Care Diagnostics (POC's), Polymerase Chain Reaction (PCR), Temperature Gradient Focusing (TGF) to cite few prominent examples. In the past decade, researchers have used various techniques to sense and control the temperature in microfluidic systems. The primary challenge has been the twin problem of integration and accuracy using minimal equipment while keeping it simple. In this study, an equipment free fabrication of the temperature sensor using filter paper impregnated with p-type colloidal PbS quantum dots is demonstrated. This sensor is later integrated into line a PDMS microfluidic device with two parallel microfluidic channels. The integrated device is chiefly to sense the difference in temperature of fluids inside the two channels. COMSOL Multiphysics 5.1 is used to simulate the single-phase laminar fluid flow and heat transfer in the microchannel of the device. The design of the microfluidic channel is optimized to decrease heat sensing times of the sensor using the simulation results.

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