In Vitro Photodynamic Studies of a BODIPY-Based Photosensitizer

Document Type

Article

Publication Date

1-3-2017

Abstract

A new halogenated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative was designed as a singlet-oxygen photosensitizer (PS) for use as a photodynamic therapy (PDT) agent, and its photophysical properties were characterized. The PS, having two iodine atom substituents, exhibited a low fluorescence quantum yield (ΦFL) of 0.02 and high singlet-oxygen-generation quantum yield (ΦΔ) of 0.93. Furthermore, in vitro photodynamic activities were evaluated to assess the potential of using the PS for PDT. A propidium iodide (PI) fluorescence assay and live-cell imaging of Lewis lung carcinoma (LLC) cells demonstrated that the cellular damage is induced by the photosensitization of the BODIPY dye, which subsequently leads to cell death by necrosis.q.

Identifier

85007276061 (Scopus)

Publication Title

European Journal of Organic Chemistry

External Full Text Location

https://doi.org/10.1002/ejoc.201601054

e-ISSN

10990690

ISSN

1434193X

First Page

25

Last Page

28

Issue

1

Volume

2017

Grant

CBET-1517273

Fund Ref

National Science Foundation

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