Identification of a novel spinal nociceptive-motor gate control for aδ pain stimuli in rats

Document Type

Article

Publication Date

5-24-2017

Abstract

Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. Here, high-speed videography during nociceptive Ad fiber stimulation demonstrated engagement of a multi-segmental motor program coincident with, or even preceding, withdrawal of the stimulated paw. The motor program included early head orientation and adjustments of the torso and un-stimulated paws. Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hindlimbs and which was partially dependent on the endogenous opioid system. These data reveal a profound, immediate and precise integration of nociceptive inputs with ongoing motor activities leading to the initiation of complex, yet behaviorally appropriate, response patterns and the mobilization of a new type of analgesic mechanism within this early temporal nociceptive window.

Identifier

85021107464 (Scopus)

Publication Title

Elife

External Full Text Location

https://doi.org/10.7554/eLife.23584.001

e-ISSN

2050084X

PubMed ID

28537555

Volume

6

Grant

ZIANS003022

Fund Ref

National Institute of Neurological Disorders and Stroke

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