The choice of a performance indicator of release in transdermal drug delivery systems

Document Type

Syllabus

Publication Date

1-1-2018

Abstract

An effective time constant for first-order processes is defined to capture the dynamics of systems represented by partial differential equations. In this chapter, the methodology is applied to passive and electrically assisted drug controlled transdermal delivery devices in two case studies. The analysis, which is carried out using Laplace-transformed variables, results in a first-order approximation and does not require time-domain solutions. Numerical experiments are included to illustrate the effectiveness of the index under different conditions and to estimate the time it takes to establish a steady-state flux across the membrane.

Identifier

85028926737 (Scopus)

Publication Title

Lecture Notes in Applied and Computational Mechanics

External Full Text Location

https://doi.org/10.1007/978-3-319-59548-1_4

ISSN

16137736

First Page

49

Last Page

64

Volume

84

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