Age and HIV effects on resting state of the brain in relationship to neurocognitive functioning
Document Type
Article
Publication Date
5-15-2018
Abstract
This study examined the effects of age and HIV infection on the resting state (RS) functional connectivity (FC) of the brain and cognitive functioning. The objective was to evaluate the moderating role of age and HIV on the relationship between RS-FC and cognition. To examine RS-FC we implemented the Independent Component Analysis (ICA) and Regional Homogeneity (ReHo). Neurocognition was evaluated with comprehensive battery of standardized neuropsychological tests. Age and HIV were entered as the independent variables. The independent effects of age, HIV, and interaction effects of age-HIV on RS-fMRI measures (ICA, ReHo) were tested in 108 participants (age M = 42). RS-FC indices that exhibited age-HIV interactions were entered into further analysis. Bivariate correlation analysis was performed between the retained RS-FC indices and T-scores of neurocognitive domains (Attention, Executive, Memory, Psychomotor, Semantic Skills). Multivariate regression modeling determined the impact of age and HIV on these relationships. We found that in the ICA measures, HIV-seropositivity was decreasing RS-FC in the left middle occipital gyrus (p <.001). Age-HIV interaction was observed in the left superior frontal gyrus (LSupFrontG), where FC was decreasing with age in HIV+ (p <.001) and increasing in HIV− (p =.031). ReHo indices did not reveal significant effects. HIV strengthened the relationship between RS-FC in LSupFrontG, Memory and Psychomotor Factor scores. Aging weakened those relationships only in control group. In sum, age-HIV interaction effects are prominent rather in remote than local RS-FC. Seroconversion strengthens relationships between intrinsic brain activity and neurocognition, but no acceleration with years of age was noted in HIV+ individuals.
Identifier
85042001570 (Scopus)
Publication Title
Behavioural Brain Research
External Full Text Location
https://doi.org/10.1016/j.bbr.2018.02.007
e-ISSN
18727549
ISSN
01664328
PubMed ID
29425918
First Page
20
Last Page
27
Volume
344
Grant
UMO-2012/06/M/H56/00316
Fund Ref
Narodowe Centrum Nauki
Recommended Citation
Egbert, Anna R.; Biswal, Bharat; Karunakaran, Keerthana; Gohel, Suril; Pluta, Agnieszka; Wolak, Tomasz; Szymańska, Bogna; Firląg-Burkacka, Ewa; Sobańska, Marta; Gawron, Natalia; Bieńkowski, Przemysław; Sienkiewicz-Jarosz, Halina; Ścińska-Bieńkowska, Anna; Bornstein, Robert; Rao, Stephen; and Łojek, Emilia, "Age and HIV effects on resting state of the brain in relationship to neurocognitive functioning" (2018). Faculty Publications. 8679.
https://digitalcommons.njit.edu/fac_pubs/8679
