The Long Noncoding RNA Landscape in Amygdala Tissues from Schizophrenia Patients

Document Type

Article

Publication Date

8-1-2018

Abstract

To date, most transcriptome studies of schizophrenia focus on the analysis of protein-coding genes. Long noncoding RNAs (lncRNAs) are emerging as key tissue-specific regulators of cellular and disease processes. The amygdala brain region has been implicated in the pathophysiology of schizophrenia. We performed unbiased whole transcriptome profiling of amygdala tissues from 22 schizophrenia patients and 24 non-psychiatric controls using RNA-seq. We reconstructed amygdala transcriptome and employed systems biology approaches to annotating the functional roles of lncRNAs. As a result, we identified 839 novel lncRNAs in amygdala. We found in amygdala lncRNAs are more subtype-specific than protein-coding genes. We identified functional modules associated with “synaptic transmission” “ribosome” and “immune responses” which were related to schizophrenia pathophysiology that involved lncRNAs. Integrative functional analyses associating individual lncRNAs with specific pathways and functions further show that amygdala lncRNAs are connected with all of these pathways. Our study presents the first systematic landscape of lncRNAs in amygdala tissue from schizophrenia cases.

Identifier

85050826286 (Scopus)

Publication Title

Ebiomedicine

External Full Text Location

https://doi.org/10.1016/j.ebiom.2018.07.022

e-ISSN

23523964

PubMed ID

30077719

First Page

171

Last Page

181

Volume

34

Grant

MH096891-03S1

Fund Ref

National Institutes of Health

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