Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration

Document Type

Article

Publication Date

9-10-2018

Abstract

Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostructured alternatives are being investigated due to favorable factors, such as sustained efficacy and high-density epitope presentation of functional moieties. These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. We discuss possible approaches to integrate the functionality of such angiogenic peptide mimics into self-assembled peptide scaffolds for application in functional tissue regeneration.

Identifier

85052849711 (Scopus)

Publication Title

Biomacromolecules

External Full Text Location

https://doi.org/10.1021/acs.biomac.8b01137

e-ISSN

15264602

ISSN

15257797

PubMed ID

30132656

First Page

3597

Last Page

3611

Issue

9

Volume

19

Fund Ref

National Science Foundation

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