Self-assembly of an antiangiogenic nanofibrous peptide hydrogel

Document Type

Article

Publication Date

9-17-2018

Abstract

Pathological neovascularization may cause or worsen intraocular posterior segment diseases such as diabetic retinopathy. Prevention of aberrant vascularization is thus an important clinical target. Therapeutic antiangiogenic agents are generally used in diffusible monomeric formulation (e.g., injection of anti-VEGF monoclonal antibodies into the vitreous humor). Here, we report the attachment of a therapeutic antiangiogenic motif to a fibrillizing peptide backbone that undergoes nanofibrous self-assembly into an injectable hydrogel. The peptide can persist for extended periods in a target site, prolonging the therapeutic time frame. The injectability of the hydrogel was investigated through rheometric characterization. Biophysical characterization was complemented by in vitro assays to test the antiangiogenic capability of the scaffold. We also tested persistence and biocompatibility of the hydrogel through in vivo implantation. This injectable hydrogel therapy may unlock potential clinical routes for treating neovascular diseases.

Identifier

85063758889 (Scopus)

Publication Title

ACS Applied Bio Materials

External Full Text Location

https://doi.org/10.1021/acsabm.8b00283

e-ISSN

25766422

PubMed ID

34996179

First Page

865

Last Page

870

Issue

3

Volume

1

Fund Ref

National Science Foundation

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