Carbon Fiber Electrodes for in Vivo Spinal Cord Recordings

Document Type

Conference Proceeding

Publication Date

10-26-2018

Abstract

Development of micro electrode arrays for neural recording is an active field that thrives on novel materials and fabrication techniques offered by micro fabrication technology. The material and mechanical properties of microelectrode arrays have a critical role on the quality and longevity of neural signals. In this study, carbon fiber microelectrode (CFME) bundles were developed and implanted in the spinal cord of experimental animals for in vivo recording. Neural data analysis revealed that single spikes could successfully be recorded and sorted. Removal of approximately 75 μ of the parylene-C coating at the tips of the fibers increased the signalto-noise ratio. Connecting multiple (three) carbon fiber filaments to the same recording channel did not deteriorate the signal quality compared to that of undesheathed fibers. Immunohistochemistry showed that electrode tips were splayed in tissue after implantation and CF bundles had a small footprint with mild encapsulation around them. These results are very promising for the use of CFME bundles for recordings of spinal cord signals in behaving animals.

Identifier

85056667266 (Scopus)

ISBN

[9781538636466]

Publication Title

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

External Full Text Location

https://doi.org/10.1109/EMBC.2018.8513408

ISSN

1557170X

PubMed ID

30441480

First Page

5069

Last Page

5072

Volume

2018-July

Grant

1RO1 NS072385

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