Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

Authors

Karthik Sambath, New Jersey Institute of Technology
Tinghan Zhao, New Jersey Institute of Technology
Zhaoxiong Wan, New Jersey Institute of Technology
Yuanwei Zhang, New Jersey Institute of Technology

Document Type

Article

Publication Date

1-1-2019

Abstract

A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.

Identifier

85075665734 (Scopus)

Publication Title

Chemical Communications

External Full Text Location

https://doi.org/10.1039/c9cc07199g

e-ISSN

1364548X

ISSN

13597345

PubMed ID

31701102

First Page

14162

Last Page

14165

Issue

94

Volume

55

Recommended Citation

Sambath, Karthik; Zhao, Tinghan; Wan, Zhaoxiong; and Zhang, Yuanwei, "Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells" (2019). Faculty Publications. 7871.
https://digitalcommons.njit.edu/fac_pubs/7871