Cellular-level understanding of supraspinal control: what can be learned from zebrafish?

Document Type

Article

Publication Date

4-1-2019

Abstract

Electrical stimulation of various brainstem nuclei has revealed sites capable of initiating and modulating locomotion. However, subsequent experiments have revealed that these regions are functionally heterogeneous. Modern techniques including molecular-genetic methods to label cell types and optogenetic approaches to manipulate neural activity are now enabling functional examination at the cellular level. In this review, we will highlight recent work revealing distinct roles for neurons of defined neurotransmitter identity and show how comparisons across species can stimulate new experimental and analytical approaches to further our understanding of how supraspinal populations function at a cellular level to control precise aspects of behaviour.

Identifier

85063039608 (Scopus)

Publication Title

Current Opinion in Physiology

External Full Text Location

https://doi.org/10.1016/j.cophys.2019.01.013

e-ISSN

24688673

ISSN

24688681

First Page

141

Last Page

145

Volume

8

Grant

101195/Z/13/Z

Fund Ref

Wellcome Trust

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