Sensorimotor Transformations in the Zebrafish Auditory System

Document Type

Article

Publication Date

12-2-2019

Abstract

Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.

Identifier

85075370316 (Scopus)

Publication Title

Current Biology

External Full Text Location

https://doi.org/10.1016/j.cub.2019.10.020

ISSN

09609822

PubMed ID

31708392

First Page

4010

Last Page

4023.e4

Issue

23

Volume

29

Grant

ANR-11-IDEX-0001

Fund Ref

Horizon 2020 Framework Programme

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