Cancer nanomedicine: From targeted delivery to combination therapy

Document Type

Article

Publication Date

4-1-2015

Abstract

The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of various diseases, including cancer. The unique properties of nanoparticles (NPs), such as large surface-to-volume ratio, small size, the ability to encapsulate various drugs, and tunable surface chemistry, give them many advantages over their bulk counterparts. This includes multivalent surface modification with targeting ligands, efficient navigation of the complex in vivo environment, increased intracellular trafficking, and sustained release of drug payload. These advantages make NPs a mode of treatment potentially superior to conventional cancer therapies. This review highlights the most recent developments in cancer treatment using NPs as drug delivery vehicles, including promising opportunities in targeted and combination therapy.

Identifier

84925769724 (Scopus)

Publication Title

Trends in Molecular Medicine

External Full Text Location

https://doi.org/10.1016/j.molmed.2015.01.001

e-ISSN

1471499X

ISSN

14714914

PubMed ID

25656384

First Page

223

Last Page

232

Issue

4

Volume

21

Grant

U54CA151884

Fund Ref

National Institutes of Health

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