Molecular recognition of pyrimidine nucleobases by triplex DNA receptors

Document Type

Article

Publication Date

4-1-2015

Abstract

Triplex DNA receptors are known for their strong and specific binding of a variety of purine ligands. However, not many studies have been reported on their binding of pyrimidine ligands. Here we used fluorophore-labeled DNA receptors to study these binding interactions. The results suggest that in general, cytosine binds more strongly than thymine and uracil, although the selectivity between two pyrimidine ligands can be tuned by changing the surrounding nucleobases of the DNA receptor. In contrast, binding of pyrimidine nucleosides is much weaker, possibly due to lack of the N1 hydrogen bonding donor.

Identifier

84925517423 (Scopus)

Publication Title

Bioorganic and Medicinal Chemistry Letters

External Full Text Location

https://doi.org/10.1016/j.bmcl.2015.02.019

e-ISSN

14643405

ISSN

0960894X

PubMed ID

25740158

First Page

1520

Last Page

1524

Issue

7

Volume

25

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