Porous hollow fiber membrane-based continuous technique of polymer coating on submicron and nanoparticles via antisolvent crystallization

Document Type

Article

Publication Date

5-20-2015

Abstract

This paper introduces a facile antisolvent crystallization technique to continuously coat submicron and nanosized particles with a thin polymer layer using a porous hollow fiber membrane device. Submicron (550 nm) and nanosized (12 nm) silica particles were the host particles; Eudragit RL 100 and poly(lactide-co-glycolide) were the coating polymers. A suspension of the particles in an acetone solution of the polymer was continuously pumped through the shell-side of a hollow fiber membrane module. The antisolvent (water) flowing in the hollow fiber lumen was forced through the membrane pores into the shell-side liquid, generating intense mixing with the flowing suspension and rapid precipitation of the polymer, coating the particles. Coated silica particles collected in a vacuum filtration device were analyzed after vacuum drying using scanning electron microscopy, scanning transmission electron microscopy, energy dispersive spectrometry, laser diffraction spectroscopy, and thermogravimetric analysis. These results indicate that a thin polymer coating of the submicron particles and nanoparticles of silica can be developed by this novel antisolvent crystallization technique using two widely different polymers. This continuous method is amenable to convenient scale-up.

Identifier

84930210941 (Scopus)

Publication Title

Industrial and Engineering Chemistry Research

External Full Text Location

https://doi.org/10.1021/acs.iecr.5b00155

e-ISSN

15205045

ISSN

08885885

First Page

5237

Last Page

5245

Issue

19

Volume

54

Grant

1100622

Fund Ref

National Science Foundation

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