A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability
Document Type
Article
Publication Date
8-17-2015
Abstract
Summary Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons. This current is driven by the rhythmic expression of NCA localization factor-1, linking the molecular clock to ion channel function. In the evening, basal potassium currents peak to silence clock neurons. Remarkably, daily antiphase cycles of sodium and potassium currents also drive mouse clock neuron rhythms. Thus, we reveal an evolutionarily ancient strategy for the neural mechanisms that govern daily sleep and wake.
Identifier
84939246366 (Scopus)
Publication Title
Cell
External Full Text Location
https://doi.org/10.1016/j.cell.2015.07.036
e-ISSN
10974172
ISSN
00928674
PubMed ID
26276633
First Page
836
Last Page
848
Issue
4
Volume
162
Grant
CA060553
Fund Ref
National Institutes of Health
Recommended Citation
Flourakis, Matthieu; Kula-Eversole, Elzbieta; Hutchison, Alan L.; Han, Tae Hee; Aranda, Kimberly; Moose, Devon L.; White, Kevin P.; Dinner, Aaron R.; Lear, Bridget C.; Ren, Dejian; Diekman, Casey O.; Raman, Indira M.; and Allada, Ravi, "A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability" (2015). Faculty Publications. 6839.
https://digitalcommons.njit.edu/fac_pubs/6839
