Enzymatic synthesis of dipeptides in ionic liquids

Document Type

Article

Publication Date

3-1-2010

Abstract

Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF 6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis. © 2010 Bentham Science Publishers Ltd.

Identifier

77951430489 (Scopus)

Publication Title

Letters in Organic Chemistry

External Full Text Location

https://doi.org/10.2174/157017810790796318

ISSN

15701786

First Page

168

Last Page

171

Issue

2

Volume

7

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