Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates
Document Type
Conference Proceeding
Publication Date
6-8-2010
Abstract
Three-dimensional (3D) nervous tissue constructs were developed using a compliant gel matrix and a fiber component for promoting contact-guided axon outgrowth. Rat embryonic (E15) dorsal root ganglion explants (DRGs) were cultured on biodegradable poly-L-lactic acid (PLLA) and wet-spun type I collagen fibers embedded in soft collagen gels. Gel constructs containing fibers induced greater axon outgrowth distances with significantly more directionality along the aligned fibers. Interestingly, wet-spun type I collagen from rat tail tendon displayed a highly aligned outgrowth pattern from DRG axons suggesting potential use for peripheral nerve repair. ©2010 IEEE.
Identifier
77953063919 (Scopus)
ISBN
[9781424468799]
Publication Title
Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference Nebec 2010
External Full Text Location
https://doi.org/10.1109/NEBC.2010.5458119
Recommended Citation
Siriwardane, M. L. and Pfister, B. J., "Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates" (2010). Faculty Publications. 6265.
https://digitalcommons.njit.edu/fac_pubs/6265
