Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds
Document Type
Conference Proceeding
Publication Date
6-8-2010
Abstract
This study evaluated the neural differentiation of human neural stem /progenitor cells (hNPCs) on electrospun fibrous piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds. We hypothesize aligned fibrous piezoelectric scaffold would provide both physical cues (via contact guidance) and local electrical activity to promote neuronal differentiation and neurite extension. hNPCs predominately differentiated into the neuronal lineage on both random and aligned electrospun PVDF-TrFE scaffolds. Less nestin-positive hNPCs were present on the scaffolds compared to laminin coated surface. The results suggest the potential use of these scaffolds in spinal cord repair and other neural applications. ©2010 IEEE.
Identifier
77953071156 (Scopus)
ISBN
[9781424468799]
Publication Title
Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference Nebec 2010
External Full Text Location
https://doi.org/10.1109/NEBC.2010.5458264
Recommended Citation
Lee, Y. S.; Collins, G.; and Arinzeh, T. Livingston, "Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds" (2010). Faculty Publications. 6250.
https://digitalcommons.njit.edu/fac_pubs/6250
