Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications
Document Type
Conference Proceeding
Publication Date
6-8-2010
Abstract
ECM is useful in providing growth and support to the cells as well as engineered tissues. There are various techniques for producing artificial matrix constructs to simulate the ECM. These include wet spinning, phase separation, dry spinning, and electrospinning. Electrospinning has advantages over other techniques as it can produce scaffolds which have a high surface area to volume ratio. Electrospinning is also capable of producing nanofibers from synthetic polymers as well as from natural polymers Ref [1]. Gelatin has been electrospun from several different solvents Ref. [2]. In this work we have chosen water as the solvent because of its inherent noncytotoxicity. When gelatin is dissolved in water it will form a semi-solid gel. Heating the solution will prevent the formation of gel. Electrospun gel fibers will dissolve in water and physiological fluids. To overcome the gelation, an apparatus has been constructed that allows gel solution to be electrospun at elevated temperature. ©2010 IEEE.
Identifier
77953065756 (Scopus)
ISBN
[9781424468799]
Publication Title
Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference Nebec 2010
External Full Text Location
https://doi.org/10.1109/NEBC.2010.5458180
Recommended Citation
Pandya, Deep S.; Arinzeh, Treena; and Collins, George, "Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications" (2010). Faculty Publications. 6247.
https://digitalcommons.njit.edu/fac_pubs/6247
